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Born in The Bronx, New York, Buono was raised in a blue-collar family and decided at an early age to make acting her life's ambition. At 11, she showed her connection to her family's work ethic by answering a casting call ad for Harvey Fierstein's "Spookhouse" and landing the role, without any assistance from her family or other adults. Buono began landing roles on television and the New York stage while in her teens and early twenties, and earned a Daytime Emmy nomination as a young victim of sexual abuse in Abby, My Love (1991) (CBS, 1991), which aired as part of the CBS Schoolbreak Special (1984). She soon graduated to minor roles in Stephen Gyllenhaal's Waterland (1992), with Jeremy Irons and Ethan Hawke; as an illegal immigrant in The Cowboy Way (1994), with Woody Harrelson and Kiefer Sutherland; and in Noah Baumbach's much-loved indie comedy, Kicking and Screaming (1995), which reunited her with her "Abby, My Love" co-star, Josh Hamilton. While cultivating her acting career, Buono also graduated from Columbia University with a double major in English and political science in 1995, which she earned in just three years. After graduation, Buono concentrated largely on character roles in independent films and on television. She was the wife and confidante of prison guard Robert Sean Leonard, who served as an earpiece for monstrous 1930s criminal Carl Panzram (James Woods) in Killer: A Journal of Murder (1995), before playing an accident-prone opera singer in love with a young man (Gibson Frazier) with Jazz-Era affectations in the offbeat Man of the Century (1999). She soon added behind-the-camera credits to her expanding resume, including writer/director on the short, Baggage (1997), with Liev Schreiber and Minnie Driver, and served as co-producer and star of the comedy, Two Ninas (1999), about a pair of similarly monikered women (Buono and Amanda Peet) who fell for a very unlucky man. She continues to write and co-wrote "When the Cat's Away" (1999), with Brad Anderson, and wrote an adaptation of F. Scott Fitzgerald's first novel, "This Side of Paradise". Buono's screen credits grew more obscure at the launch of the new millennium - art house and film festival circles saw the lesbian drama, Chutney Popcorn (1999), Attention Shoppers (2000), Happy Accidents (2000) with Marisa Tomei and Vincent D'Onofrio. She soon turned to television for wider exposure, and earned it through supporting roles on high profile series like Third Watch (1999) and The Sopranos (1999). In 2007, she joined the cast of the cult favorite, The Dead Zone (2002) (USA, 2002-2007) as Sheriff Anna Turner, who investigated the death of her predecessor (Chris Bruno). During this period, Buono maintained her screen career in features as varied as Ang Lee's Hulk (2003), playing David Banner's mother, who was killed by his genetically-induced rage, and Beer League (2006), and Artie Lange's hapless lay-about love interest. In 2010, she appeared as the divorced mother of Kodi Smit-McPhee in Let Me In (2010), the critically-praised American remake of the Swedish vampire movie, Let the Right One In (2008). That same year, she landed her most widely seen role-to-date on Mad Men (2007), playing Dr. Faye Miller. For her efforts, Buono received an Emmy Award nomination for Outstanding Guest Actress in a Drama Series in 2011.
Filmography
Movies and shows, newest first
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2026
The Debut
Movie Cassie
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2026
Jane
Movie Linda Carson
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2026
One Last Adventure: The Making of Stranger Things 5
Movie Self - Karen Wheeler
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2025
Things Like This
Movie Margie Kitlin
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2025
V13
Movie Ida
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2025
Queen of the Ring
Movie Bertha Burke
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2024
In Fidelity
Movie Holly Ayker
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2024
Always, Already
Movie Cara
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2023
The Girl Who Escaped: The Kara Robinson Story
Movie Debra
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2023
She Came from the Woods
Movie Heather McCalister
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2022
The Girl from Plainville
TV show Gail Carter
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2020
Talking Sopranos
TV show Self
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2018
The Romanoffs
TV show Debbie Newman
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2018
God Friended Me
TV show Karen
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2018
Monsters and Men
Movie Stacey
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2018
The Bad Seed
Movie Angela
More credits
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2017
All Saints
Movie Aimee Spurlock
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2017
The Blacklist: Redemption
TV show Anna Copeland
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2016
Bull
TV show Amaya Andrews
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2016
Half the Perfect World
Movie Sonia
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2016
Stranger Things
TV show Karen Wheeler
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2015
Supergirl
TV show Gamemnae / Gemma Cooper
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2015
Emily & Tim
Movie Emily (Segment 3)
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2015
Paper Towns
Movie Mrs. Jacobsen
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2014
A Good Marriage
Movie Betty Pike
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2014
The Mysteries of Laura
TV show Julia Davis
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2014
The Discoverers
Movie Nell
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2014
Drew Peterson: Untouchable
Movie Kathleen Savio
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2012
Modern Love
Movie Nicky
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2012
Elementary
TV show Sarah Cushing
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2011
Person of Interest
TV show Martine Rousseau
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2010
Let Me In
Movie Owen's Mother
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2010
Hawaii Five-0
TV show Agent Allison Marsh
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2010
Betrayed
Movie Amy Waite
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2009
The Good Wife
TV show Charlene Peterson
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2009
Castle
TV show Siobhan O'Doul
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2008
Cthulhu
Movie Dannie
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2008
The Unquiet
Movie Julie Bishop
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2007
Mad Men
TV show Faye Miller
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2006
Brothers and Sisters
TV show Rose